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The second most important Madrid bus station is Avenida de América, very well connected with the Metro and the airport.
This bus station mainly serves north and northeast destinations and almost all the routes operating from Avenida de América belong to Alsa (the exception being a couple of routes to Pamplona and Logroño).
Alsa is the most important bus company in Spain. It operates domestic and international routes. Its buses depart from Madrid’s two most important bus stations (Avenida de América and Estación Sur) and from Barajas airport Terminal 4 (T4).
Estación Avenida de América is in the northeast of Madrid. The exact address is c/ Avenida de América, 9.
There is a Metro station inside the premises, Avenida de América, with access to lines 4 (brown), 6 (grey), 7 (orange) and 9 (purple).
Alternatively, from Barajas airport, you can catch bus line 200, linking Terminals 1, 2 and 4 (T1, T2 and T4) with the bus station.
Obviously, you can also get there by bus (12, 29, 52, 72, 73, 114, 15, 122, 200, C1, C2, N2, N4) and taxi.
Read more information about getting to Madrid by bus.